TENZURES ™-M

10X10 Tablets

TENZURES™-M is a combination of Teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin Hydrochloride (Extended Release), a biguanide class oral antidiabetic drug. This formulation is designed to control blood glucose levels in patients with type 2 diabetes mellitus (T2DM) when diet and exercise alone are insufficient. The synergistic effect of Teneligliptin and Metformin helps achieve better glycemic control, reduces fasting and postprandial glucose levels, and improves overall metabolic profile.

• Common: Nausea, vomiting, diarrhea, abdominal discomfort, headache, dizziness.

• Less common: Hypoglycemia (rare when used alone), constipation, fatigue.

• Rare but serious: Lactic acidosis (with metformin), pancreatitis (with DPP-4 inhibitors), hypersensitivity reactions.

• Administered orally once or twice daily, depending on dosage strength.

• To be taken with meals to reduce gastrointestinal side effects.

• Swallow tablet whole; do not crush or chew extended-release tablets.

• Risk of lactic acidosis (serious but rare, requires immediate medical attention).

• Use with caution in patients with renal, hepatic, or cardiac impairment.

• Long-term use may cause Vitamin B12 deficiency (from metformin).

• Not a substitute for diet, exercise, and lifestyle modifications.

• Known hypersensitivity to Teneligliptin, Metformin, or any excipients.

• Patients with severe renal impairment (eGFR <30 ml/min/1.73m²).

• Metabolic acidosis, including diabetic ketoacidosis.

• Severe liver disease or history of pancreatitis.

• Excessive alcohol intake or conditions predisposing to hypoxia (e.g., heart failure, respiratory failure).

• Lactic Acidosis Risk: Stop immediately if unexplained acidosis symptoms (muscle pain, drowsiness, rapid breathing) appear.

• Renal Impairment: Dose adjustment or discontinuation required.

• Elderly Patients: Use with caution due to reduced renal clearance.

• Pregnancy & Lactation: Use only if benefits outweigh risks.

• Alcohol: Avoid excessive consumption to reduce risk of lactic acidosis.

• As directed by the physician.

• Typically once or twice daily depending on severity and clinical profile.

• To be taken with meals to minimize gastrointestinal side effects.

• Do not crush or chew extended release tablets.

• Other antidiabetic agents (sulfonylureas, insulin) → risk of hypoglycemia.

• Alcohol → increases risk of lactic acidosis.

• Iodinated contrast media → temporary discontinuation recommended.

• Drugs impairing renal function (NSAIDs, diuretics) → may increase metformin toxicity.

• Beta-blockers → may mask hypoglycemia symptoms

• Take exactly as prescribed.

• Do not skip or double doses.

• Maintain regular blood sugar monitoring.

• Follow a healthy diet & exercise regimen.

• Inform the doctor before any surgery or radiological procedure requiring contrast media.

• Storage: Store in a cool, dry place away from light and moisture.

• Pack Size: As per company standard packaging.

• American Diabetes Association. Standards of Medical Care in Diabetes – 2025.

• Indian Council of Medical Research (ICMR) Guidelines for Management of Type 2 Diabetes.

• Teneligliptin clinical trial data – PubMed indexed studies.

• Metformin prescribing information (FDA/EMA).