ROSVANTA™ - CV

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ROSVANTA™ - CV is a combination of Rosuvastatin and Clopidogrel. It is used orally to reduce the level of bad cholesterol and fats in your body. High levels of cholesterols and fats increase the risk of heart attack and stroke. This medicine works by reducing the formation of cholesterols and fats in your body and decreasing the formation of harmful blood clots. 

ROSVANTA™ - CV shows common side effects like stomach pain, indigestion, constipation and headache. Consult your doctor if the side effects persist or worsen. This medicine increases the risk of bleeding in the body, so be careful while using sharp objects or doing any work that has a risk of causing damage to the skin. Avoid taking this medicine if you are allergic to it.

ROSVANTA™ - CV may rarely cause serious side effects. While on treatment with this medication, notify your doctor if you are more tired than usual, do not feel hungry, or if you have yellow eyes or skin. Consult your doctor at the earliest if you experience muscle pain or weakness, particularly if it is accompanied by fever.

ROSVANTA™ - CV can be taken with or without food. The dose and duration of treatment will depend on what you are being treated for. Take this medicine at the same time every day for ease of remembering and to avoid missing the dose. Do not stop taking it until you have finished the complete course of treatment, even when you feel better.

ROSVANTA™ - CV can interact with other medications and health conditions. Share your entire medical history of kidney/liver problems, bleeding disorder etc. with your doctor. You should also let your doctor know about all other medicines you are taking as they may affect ROSVANTA™ - CV Capsule. Inform the doctor if you are pregnant, planning a pregnancy or are breastfeeding.

Major & minor side effects for ROSVANTA™ - CV Capsule

• Muscle pain
• Tenderness
• Weakness
• Headache
• Joint pain
• Acid or sour stomach
• Diarrhoea
• Excessive air or gas in stomach
• Redness of the skin especially on the face and neck
• White patches in the mouth or on the tongue
• Difficulty in breathing
• Blood in urine and stools
• Change in taste
• Loss of appetite
• Constipation
• Yellowing of skin and eyes

What is it prescribed for?
Hyperlipidemia
Hyperlipidemia is a condition characterized by high levels of lipids in your blood. ROSVANTA™ - CV is used in this condition to lower down the lipid levels in your blood.
Hypertriglyceridemia
Hypertriglyceridemia is a condition characterized by elevated levels of triglycerides, a type of fat. ROSVANTA™ - CV is used in this condition to lower down the levels of fats in your blood.
Homozygous Familial Hypercholesterolemia
Homozygous Familial Hypercholesterolemia is a genetic disorder characterized by high cholesterol levels. ROSVANTA™ - CV is used to lower the cholesterol levels in your body. 
Prevention of cardiovascular diseases
ROSVANTA™ - CV is used to reduce the risk of heart attacks by reducing the levels of bad cholesterol in your blood. High cholesterol levels get accumulated in your blood vessels (coronary artery) and narrow or block the blood vessels leading to the interrupted blood supply to your heart. 
Prevention of Stroke
ROSVANTA™ - CV is used to reduce the risk of stroke by reducing the levels of bad cholesterol in your blood. A stroke occurs when a blockage in the blood vessels interrupt or reduces blood supply to your brain. It can also occur when high cholesterol levels get accumulated in your blood vessels (carotid artery) and narrows or blocks the blood vessels leading to the interrupted blood supply to your brain.
Peripheral Arterial Disease
ROSVANTA™ - CV is used in the treatment of peripheral artery disease. In this condition, there is a blockage of the blood vessels (that carry blood to limbs) due to the accumulation of cholesterol or blood clot.

Commonly asked questions
How long does it take for this medicine to take effect?
ROSVANTA™ - CV may start to show its action within 1 hour of taking it orally. However, it can take up to few days to weeks to make you feel better. 
How long do the effects of this medicine last?
ROSVANTA™ - CV may remain active in the body for about 24 hours. 
Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Is this a habit forming medicine?
ROSVANTA™ - CV has no habit-forming tendency.
Can this medicine be taken during pregnancy?
ROSVANTA™ - CV is not recommended if you are pregnant as it may potentially harm your foetus. Your doctor may prescribe a safer alternative based on your clinical condition.
Can this medicine be taken while breast-feeding?
ROSVANTA™ - CV pass into the breastmilk. This may harm your infant. Discontinue breastfeeding while on ROSVANTA™ - CV treatment. Discuss the benefits and risks with your doctor before taking this medicine.   

Allergy
Avoid taking ROSVANTA™ - CV if you are allergic to it. Seek immediate medical attention if you notice any symptoms of allergic reactions such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc. 
Active liver disease
ROSVANTA™ - CV is broken down in the liver. The presence of liver problems may lead to the accumulation of this medicine in your liver. This accumulation may worsen the liver condition. Hence,  ROSVANTA™ - CV is not recommended for use if you have active liver problems.
Bleeding disorder
ROSVANTA™ - CV is not recommended for use if you have a known history of peptic ulcer(s) or any bleeding disorders due to the increased risk of bleeding.

Warnings for special population
Pregnancy
ROSVANTA™ - CV is not recommended if you are pregnant as it may potentially harm your foetus. Your doctor may prescribe a safer alternative based on your clinical condition.
Breast-feeding
ROSVANTA™ - CV pass into the breastmilk. This may harm your infant. Discontinue breastfeeding while on ROSVANTA™ - CVtreatment. Discuss the benefits and risks with your doctor before taking this medicine.   
General warnings
Cognitive impairment
ROSVANTA™ - CV may cause forgetfulness, memory loss, confusion, etc. in some people. These side effects are reversible and usually disappear once the medicine is discontinued.
Myopathy and Rhabdomyolysis
ROSVANTA™ - CV may cause myopathy (muscle pain) and rhabdomyolysis (a very serious condition in which damaged muscle fibres enter the bloodstream, leading to kidney failure) in some people, a condition that can be harmful. This may cause symptoms such as severe tiredness and weakness. This risk is especially higher in the elderly and in people with active muscle disorders.
Alcohol consumption
ROSVANTA™ - CV may cause liver and kidney injuries in people consuming alcohol very frequently and in large quantities. Hence, consumption of alcohol should be avoided during treatment with this medicine.
Discontinuation of Clopidogrel
Stopping the use of ROSVANTA™ - CV suddenly may increase the risk of heart problems. If treatment is interrupted in conditions like surgery or bleeding, it should be restarted as soon as possible.
Use in pediatrics
Since the safety and efficacy of ROSVANTA™ - CV use are not clinically established, this medicine may be used in children below 18 years of age only under the close supervision of the doctor.
This medicine is not recommended for use in children below six years of age.

Missed Dose
If you forget to take a ROSVANTA™ - CV dose, make sure that you remember to take your next dose on time. Do not take two doses together to make up for a forgotten dose. 
Overdose
Never take ROSVANTA™ - CV more than the prescribed dose. If you suspect that you might have taken an overdose of this medicine, go to the emergency department of your local hospital.

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

• Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

• Leflunomide
• Atazanavir
• Gemfibrozil
• Nonsteroidal anti-inflammatory drugs
• Warfarin

Disease interactions

• Diabetes

Be cautious while taking ROSVANTA™ - CV if you are diabetic. This medicine may alter your blood sugar levels. Your doctor may advise you to monitor the blood sugar levels frequently while you are on Rosuvas CV 10 Capsule.   

• Rhabdomyolysis

Be cautious while taking ROSVANTA™ - CV if you have rhabdomyolysis. Rhabdomyolysis is a very serious condition in which damaged muscle fibres enter the bloodstream, leading to kidney failure. 

Food interactions
Information not available.

Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

Take ROSVANTA™ - CV orally with food to avoid an upset stomach.
It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, or using sharp objects.

Notify your doctor if you are more tired than usual, do not feel hungry, or if you have yellow eyes, skin.
Notify your doctor if you experience muscle pain or weakness, particularly if accompanied by fever.

Let your doctor know that you are taking ROSVANTA™ - CV before undergoing any surgical procedure.
Do not open, crush or chew the capsule in your mouth. 

Miscelleneous

To be taken with food

To be taken as instructed by doctor

Effect on sleep is not established

How it works

Rosuvas CV 10 Capsule is a combination of Rosuvastatin and Clopidogrel. Rosuvastatin reduces the production of cholesterol from the liver and reduces the levels of VLDL and LDL in the blood. Clopidogrel works by preventing the formation of clots in blood vessels and helps in free blood flow.

Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Statins, Antiplatelet agents

Schedule

Schedule H

Medicines.org.uk. 2021. Rosuvastatin 10 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 16 August 2021].

https://www.medicines.org.uk/emc/product/8970/smpc>

Medicines.org.uk. 2021. Clopidogrel 75mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 13 August 2021].

https://www.medicines.org.uk/emc/product/10634/smpc#PHARMACOKINETIC_PROPS>

Stewart, M., 2021. Clopidrogel to prevent blood clots. Clopidogrel uses - Patient. [online] Patient.info. Available at: <o/medicine/clopidogrel-to-prevent-blood-clots-plavix> [Accessed 13 August 2021].

https://patient.inf

Drugs, H., 2021. Clopidogrel: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 13 August 2021].

https://medlineplus.gov/druginfo/meds/a601040.html>

nhs.uk. 2021. Rosuvastatin: a medicine used to lower cholesterol. [online] Available at: < [Accessed 13 August 2021].

https://www.nhs.uk/medicines/rosuvastatin/>