MOXIETHIX™

5 ML

MOXIETHIX™ is an antibiotic used for the treatment of bacterial infections that affect the skin, lungs, nose, eyes, stomach and intestine. This medicine is effective against a large number of bacteria. It works by blocking the action of enzymes required for bacterial multiplication. This prevents further growth and kills the infection-causing bacteria.

MOXIETHIX™ may cause some common side effects such as stomach pain, diarrhoea, nausea/vomiting, headache, dizziness, etc. Consult your doctor if these symptoms persist or if they become severe. 

MOXIETHIX™ oral forms (tablets, capsules) should be taken as prescribed by your doctor. You will start to feel better in a few days. However, continue taking the medicine for the prescribed duration. Skipping doses or not completing the full course of treatment may result in decreased effectiveness of the medicine or increased risk of re-infection that would be difficult to treat in the future. MOXIETHIX™ injection will be administered by qualified healthcare professionals in a hospital setting. MOXIETHIX™ eye/ear drops, eye ointments should be instilled in your eyes/ears as advised by your doctor. This medication is effective only for the treatment of infections caused by bacteria and not viruses.

MOXIETHIX™ is not recommended if you are allergic to it. Inform your doctor if you have diabetes, heart or liver problems before starting the treatment. Consult your doctor if you are pregnant, or are breastfeeding.

Major & minor side effects for MOXIETHIX™

• Headache
• Dizziness
• Nausea or Vomiting
• Stomach pain
• Diarrhoea
• Increased liver enzyme levels
• Anxiety and nervousness
• Change in taste
• Decreased appetite
• Muscle and joint pain
• Confusion
• Dry eyes
• Eye swelling

What is it prescribed for?

• Community-acquired pneumonia

Community-acquired pneumonia (CAP) refers to pneumonia (lung infection) that is acquired outside the hospital. CAP can be bacterial or viral. MOXIETHIX™ is used to treat CAP caused by bacteria like Mycoplasma pneumoniae, Streptococcus pneumoniae, Haemophilus influenzae, etc. 

• Skin and soft tissue infections

Skin and soft tissue infection is bacterial infection affecting the skin and its supporting structures. MOXIETHIX™ is used to treat skin and soft tissue infections caused by bacteria.

• Stomach and intestinal infections

MOXIETHIX™ is used to treat infections in your stomach and intestine caused by bacteria.

• Bronchitis

Bronchitis is the swelling of the bronchial tubes, the tube which carries the air to and from the lungs. Common symptoms include cough and shortness of breath. MOXIETHIX™ is used in the treatment of bronchitis caused by bacteria.

• Plague

Plague is a serious bacterial infection caused by Yersinia pestis. It spreads through the bite of infected fleas (wingless insects), through direct contact, or by inhalation. In severe form, it may lead to septicaemic plague (blood infection that spreads throughout the body) and/or pneumonic plague (infecting the lungs). MOXIETHIX™ is used in the prevention and treatment of plague.

• Acute bacterial sinusitis

Acute sinusitis, commonly called as sinus infection, is a swelling of the nasal passages and the surrounding cavities called sinuses. Symptoms include a stuffed nose, headache, and pain/pressure behind the eyes, nose, cheeks, or forehead. MOXIETHIX™ is used in the treatment of acute bacterial sinusitis.

• Anthrax

Anthrax is a rare but serious bacterial illness caused by Bacillus anthracis. It is transmitted through air, food, and water contaminated with anthrax spores. It may affect your skin, lungs, intestine, or the site of injection. MOXIETHIX™ is used for the prevention of anthrax. 

•  Pelvic inflammatory disease

Pelvic inflammatory disease is an infection of the reproductive organs in women. Symptoms may include fever, pain in the lower abdomen, vaginal discharge, painful/frequent urination, etc. MOXIETHIX™ is used in combination with other antibiotics for the treatment of mild to moderate pelvic inflammatory disease.

• Bacterial Conjunctivitis

Bacterial conjunctivitis, also known as pink eye, is a bacterial eye infection affecting the conjunctiva (a clear tissue covering the white part of your eyeball and lining the eyelid). This infection can easily spread by direct or indirect contact with an infected person. MOXIETHIX™ ophthalmic forms (eye drops, eye ointments) is used in the treatment of bacterial conjunctivitis. 

• Bacterial Ear Infections

MOXIETHIX™ eye/ear drops is used in the treatment of ear infections caused due to bacteria.

Commonly asked questions

Onset of action
It is not known when MOXIETHIX™ will start its action. 

Duration of effect
MOXIETHIX™, after administration of oral forms and injection, may remain in your body for 3-4 days.

Safe with alcohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?
No habit-forming tendency has been reported with MOXIETHIX™.

Usage in pregnancy?
MOXIETHIX™ oral form and injection is not recommended for use during pregnancy as it may harm your foetus. Consult your doctor if you are pregnant. 
Due to lack of adequate and well-controlled studies, MOXIETHIX™ eye drops and eye ointments may be used during pregnancy only upon your doctor's recommendation. 

Usage while breast-feeding?
MOXIETHIX™ oral form and injection is not recommended during breastfeeding as it may pass into breastmilk and harm your baby.

Consult your doctor if you are breastfeeding.
Due to lack of adequate and well-controlled studies, MOXIETHIX™ eye drops and eye ointment may be used while breastfeeding only upon your doctor's recommendation.

• Allergy

Avoid taking MOXIETHIX™ if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc. 

• Liver Disease

MOXIETHIX™ is not recommended if you have moderate to severe liver problems or high liver enzyme levels (>5 times the upper normal limit). This medicine is broken down in your liver and impaired liver function may lead to the accumulation of this medicine. Hence, it may worsen your condition and lead to further liver damage.

• Heart diseases

QT prolongation is a condition in which your heart muscles take a longer time to recharge between a heartbeat. MOXIETHIX™ can cause QT prolongation, hence it is not recommended if you have heart conditions such as heart failure (a condition in which the heart is not able to pump a sufficient amount of blood), arrhythmia (abnormal heart rhythm), electrolyte disturbances (abnormal concentration of electrolyte levels in the body) especially low potassium levels, and/or bradycardia (slow heartbeat) as it may worsen your condition.

Warnings for special population

• Pregnancy

MOXIETHIX™ oral form and injection is not recommended for use during pregnancy as it may harm your foetus. Consult your doctor if you are pregnant. 
Due to lack of adequate and well-controlled studies, MOXIETHIX™ eye drops and eye ointments may be used during pregnancy only upon your doctor's recommendation. 

• Breast-feeding

MOXIETHIX™ oral form and injection is not recommended during breastfeeding as it may pass into breastmilk and harm your baby. Consult your doctor if you are breastfeeding.
Due to lack of adequate and well-controlled studies, MOXIETHIX™ eye drops and eye ointment may be used while breastfeeding only upon your doctor's recommendation.

General warnings

• Photosensitivity

MOXIETHIX™ may make your skin more sensitive to sunlight or UV light. Therefore, you should avoid prolonged exposure to sunlight/UV light while taking this medication.

• Antibiotic resistance

Antibiotic resistance occurs when bacteria develop the ability to defeat the medicine that was intended to kill them. Hence, to avoid such resistance, you should always complete the entire course of treatment with MOXIETHIX™, even if you feel better.

• Driving or operating machines

MOXIETHIX™ may cause dizziness, confusion, or disorientation. Hence, avoid performing activities that require mental alertness such as driving vehicles or operating machines if you experience any of these symptoms.
Elderly
MOXIETHIX™ should be used with caution in elderly people as they are more susceptible to the risk of side effects. 

• Diarrhoea

MOXIETHIX™ can cause diarrhoea as this medicine may also kill the helpful bacteria in your stomach or intestine. Contact your doctor if you experience severe watery or bloody diarrhoea. Consult your pharmacist/doctor before taking anti-diarrhoeal medication. 

• Antacids

If you are taking an antacid for indigestion, it can reduce the effect of MOXIETHIX™. Hence it is recommended to take this antibiotic 2 to 4 hours before or 4 to 6 hours after taking an antacid.

• Contact lens

Avoid wearing contact lenses when you have an eye infection.

• Missed Dose

Oral forms/Eye and/or ear drops: Try not to skip a dose of MOXIETHIX™. Take/administer the missed dose as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double the dose to compensate for a missed one.

Injection: Since MOXIETHIX™ is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

• Overdose

Oral forms: Do not take more than the dose prescribed by your doctor. Contact your doctor if you suspect an overdose with MOXIETHIX™.

Eye or ear drops: Since MOXIETHIX™ eye or ear drops are intended for external use, the likelihood of side effects due to an overdose is low. However, do not administer more than the prescribed dose. 

Injection: Since MOXIETHIX™ is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by your doctor if an overdose is suspected.

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

• Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

• Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

• Escitalopram
• Ethinyl Estradiol
• Corticosteroids
• Quinidine
• Aspirin
• Antacids containing calcium/magnesium/aluminum
• Warfarin
• Metformin

Disease interactions

• Central nervous system disorders

MOXIETHIX™ may increase the risk of tremors, agitation, restlessness, anxiety, confusion, hallucinations, sleeplessness, seizures, etc. Hence treatment with this medicine should be administered cautiously if you have a history of these conditions. Inform your doctor immediately if you experience any symptoms.

• Myasthenia Gravis

Myasthenia gravis is a disorder that causes weakness of your skeletal muscles that are responsible for movement. MOXIETHIX™ should be used with caution if you have myasthenia gravis as this medicine may further cause muscle weakness and worsen your condition. Consult your doctor before taking this medicine.

• Peripheral Neuropathy

Peripheral neuropathy is a condition of nerve damage resulting in weakness, numbness, sensitivity to touch, and pain, usually in the hands and feet. MOXIETHIX™ should be used with caution as it may cause peripheral neuropathy. Consult your doctor if you experience any symptoms or if they become severe.

• Tendonitis or tendon rupture

Tendon is the connective tissue that joins muscle to the bone. MOXIETHIX™ may increase the risk of tendonitis (swelling of the tendon) and tendon rupture (a partial or complete tear of your tendon). Avoid taking MOXIETHIX™ if you have a history of these conditions.

• Diabetes

If you have diabetes, MOXIETHIX™ should be used with caution as it may alter your blood sugar levels. Regularly monitor your blood sugar levels while taking this medicine. 

Food interactions
Multivitamins with minerals reduce the effectiveness of MOXIETHIX™ when taken together. Hence, avoid taking multivitamins with minerals while on treatment with this medicine. If indicated for use, MOXIETHIX™ should be taken 2 to 4 hours before or 4 to 6 hours after taking medicines containing magnesium, aluminum, calcium, iron and/or other minerals.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

Oral forms: Take MOXIETHIX™ with or without food as prescribed by your doctor. Do not take more or less than the prescribed dose. 

Avoid taking antacids and/or multivitamins containing minerals along with MOXIETHIX™ as it may decrease the effectiveness of this medication.

Avoid recommending MOXIETHIX™ to other people even if their condition appears to be the same as yours. Taking antibiotics without your doctor's recommendation may cause the bacteria to be resistant to the given medicine and it may be difficult to treat in the future. 

Use MOXIETHIX™ at around the same time daily for the ease of remembering. Ensure that your complete the course of the treatment.

Avoid driving or operating machines after taking this medicine as it may affect your alertness. 

MOXIETHIX™ may affect liver enzymes levels. Therefore, your doctor may closely monitor your liver function and liver enzyme levels while you take this medicine.

Injection: MOXIETHIX™ should be administered by a qualified healthcare professional in the clinical or hospital setting. Your doctor will determine an appropriate dose based on your clinical condition. 

Other forms: MOXIETHIX™ eye/ear drops and eye ointment is for external use only. Administer it as directed by your doctor. 

Do not touch your eyes with unwashed hands. Avoid sharing items like eyeglasses, contact lenses, pillows, towels, clothes, eye or face makeup when you are infected.

Miscelleneous
Can be taken with or without food, as advised by your doctor
To be taken as instructed by doctor
May cause sleepiness

How it works
MOXIETHIX™ stops the action of a bacterial enzyme called DNA-gyrase. This helps to prevent the growth of the bacteria and eventually kills them.

Legal Status
Approved
Approved
Approved
Approved

• Classification

Category
Fluoroquinolones, Antibiotics

• Schedule

Schedule H1

Medicines.org.uk. 2021. Avelox 400 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 5 February 2021].
https://www.medicines.org.uk/emc/medicine/11841#gref>
Drugs, H., 2021. MOXIETHIX™: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 5 February 2021].
https://medlineplus.gov/druginfo/meds/a600002.html>
Stewart, M., 2021. MOXIETHIX™ For Infection - Avelox. Antibiotics; Side Effects. [online] Patient.info. Available at: <o/medicine/moxifloxacin-for-infection-avelox> [Accessed 5 January 2021].
https://patient.inf
Merck.com. 2021. [online] Available at: < [Accessed 5 February 2021].
https://www.merck.com/product/usa/pi_circulars/a/avelox/avelox_pi.pdf>
Medicines.org.uk. 2021. [online] Available at: < [Accessed 30 August 2021].
https://www.medicines.org.uk/emc/files/pil.3273.pdf>