MetGlizer™-VG 2/0.2

10x10 Tablets Blister

MetGlizer™-VG 2/0.2 is an oral antidiabetic combination therapy designed to manage Type 2 Diabetes Mellitus. It combines the insulin-sensitizing action of Metformin with the insulin-secretagogue effect of Glimepiride, providing dual glycemic control by reducing hepatic glucose production and enhancing insulin secretion.

Common:

• Hypoglycemia

• Nausea, vomiting, diarrhea, abdominal discomfort

• Headache, dizziness

• Weight gain (due to glimepiride)

Rare but Serious:

• Lactic acidosis (metformin-related)

• Allergic skin reactions

• Hepatic dysfunction

• To be used in patients with Type 2 Diabetes Mellitus not adequately controlled by diet, exercise, or monotherapy.

• Taken orally with meals to reduce gastrointestinal side effects and hypoglycemia risk.

• May cause hypoglycemia, especially in elderly or patients with irregular meal patterns.

• Risk of gastrointestinal disturbances due to metformin.

• Long-term metformin use may reduce Vitamin B12 absorption.

Avoid in patients with:

• Type 1 Diabetes Mellitus or Diabetic Ketoacidosis

• Severe renal impairment (eGFR < 30 mL/min/1.73 m²)

• Hepatic impairment

• Hypersensitivity to Metformin or Glimepiride

• Pregnancy and lactation (unless prescribed by a physician)

• History of lactic acidosis

• Risk of lactic acidosis with metformin, especially in renal impairment.

• Hypoglycemia risk with glimepiride, particularly with missed meals, alcohol intake, or strenuous exercise.

• Monitor liver and kidney function regularly.

• Use with caution in elderly, debilitated, or malnourished patients.

• As directed by the physician.

• Usual starting dose: Once daily with meals, adjusted based on blood glucose response.

• Do not crush or chew – swallow whole with water.

• Increased hypoglycemia risk: Sulfonylureas, insulin, beta-blockers, alcohol.

• Reduced efficacy: Thiazide diuretics, corticosteroids, thyroid hormones, estrogens.

• Metformin interaction: Contraindicated with iodinated contrast media (risk of lactic acidosis).

• Monitor carefully with ACE inhibitors, NSAIDs, and certain antibiotics.

✅ Take with food to minimize GI effects.
✅ Follow prescribed diet and exercise plan.
✅ Regularly monitor blood glucose and HbA1c.
✅ Do not skip meals to avoid hypoglycemia.
✅ Avoid alcohol as it increases lactic acidosis & hypoglycemia risk.
✅ Inform doctor before surgery or contrast imaging.

• Storage: Store in a cool, dry place below 25°C, protected from moisture and sunlight.

• Presentation: Blister/Alu-Alu strips of tablets.

• Schedule: Schedule H Prescription Drug – To be sold only on prescription of a Registered Medical Practitioner.

• American Diabetes Association. Standards of Medical Care in Diabetes—2025.

• International Diabetes Federation (IDF) Guidelines.

• Goodman & Gilman’s: The Pharmacological Basis of Therapeutics.

• Brunton LL, Chabner BA, Knollmann BC. Goodman & Gilman’s Pharmacotherapy of Diabetes Mellitus.