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ETHNEM-1GM
Meropenem Injection 1GM I.P
PACKING SIZE / TYPE
20ML WITH CARTON
Summary
ETHNEM-1GM is a broad-spectrum carbapenem antibiotic containing Meropenem 1GM I.P. It is designed to combat a wide variety of severe bacterial infections. Its efficacy against gram-positive, gram-negative, and anaerobic bacteria makes it a versatile choice in critical care.
Side Effects
- Common: Nausea, vomiting, headache, diarrhea, constipation
- Serious: Allergic reactions, anaphylaxis, rash, seizures, thrombocytopenia, neutropenia
- Rare: Kidney dysfunction, liver enzyme elevation
Usage
- Administered intravenously by healthcare professionals.
- Dosage and duration depend on the severity and type of infection, age, weight, and renal function.
- Reconstitute the injection as per instructions before use.
Concerns
- Resistance development due to misuse or overuse.
- High costs in resource-limited settings.
- Risk of superinfections with prolonged usage.
When not to use?
- Known hypersensitivity to Meropenem or other carbapenems.
- History of severe allergic reactions to beta-lactam antibiotics.
- Not recommended for viral infections like the common cold or flu.
Warnings
- Allergic Reactions: Monitor for signs of hypersensitivity.
- Seizures: Use with caution in patients with a history of central nervous system disorders.
- Renal Impairment: Dose adjustments required in patients with kidney dysfunction.
- Pregnancy & Lactation: Use only if the potential benefit justifies the risk.
- Drug Interactions: Avoid combining with valproic acid, as it may reduce the drug's efficacy.
Dosage
- Adults: 500 mg to 1 gm every 8 hours, depending on infection severity.
- Pediatrics: 20–40 mg/kg every 8 hours (maximum of 2 gm/day).
- Dosage adjustments needed for renal impairment (creatinine clearance ≤ 50 mL/min).
Interactions
- Valproic Acid: Decreases serum levels, reducing seizure control.
- Probenecid: Increases meropenem levels by reducing renal clearance.
- Anticoagulants: Monitor INR when used with warfarin.
General Instructions
- Store in a cool, dry place (2–8°C) and protect from light.
- Only a healthcare professional should reconstitute and administer the injection.
- Complete the prescribed course to prevent resistance, even if symptoms improve.
Other Details
- Brand Name: ETHNEM-1GM
- Category: Broad-Spectrum Antibiotic
- Formulation: Powder for injection
- Pack Size: Vial
References
-
Clinical Guidelines on Antibiotic Use - World Health Organization (WHO).
-
Meropenem Product Information - U.S. Food and Drug Administration (FDA).
-
Pharmacological Review - Journal of Antimicrobial Chemotherapy.
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