ETHIXTHIO-MR Tablets

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ETHIXTHIO-MR Tablets is a combination of Etoricoxib and Thiocolchicoside. It is a painkiller medicine that provides relief from pain and swelling associated with muscle spasms such as low back pain, neck pain, sprains/strains, etc. It works by relaxing your muscles and preventing muscle contraction. It also prevents the release of a chemical substance that causes pain and swelling in your body.

ETHIXTHIO-MR Tablets has side effects such as increased blood pressure, headache, stomach pain, heartburn, and diarrhoea. These side effects usually subside by themselves. However, consult your doctor if they remain for a long time or worsen. As this medicine may cause dizziness and drowsiness, avoid driving vehicles or operating heavy machines. 

ETHIXTHIO-MR Tablets dose and duration of treatment will be determined by your doctor based on your condition. Take this medicine as instructed by your doctor. Avoid taking more or less than the prescribed dose. For the ease of remembering and better results, take it at the same time every day. Take this medicine for the complete duration of treatment and avoid discontinuation without consulting your doctor as your symptoms may reappear.

ETHIXTHIO-MR Tablets is not recommended for use if you are allergic to it. Avoid taking this medicine if you have severe liver or kidney problems, or existing heart problems. Use this medicine with caution if you have diabetes and/or high blood cholesterol levels. 

ETHIXTHIO-MR Tablets is not recommended for use in children below 16 years of age. Inform your doctor if you are pregnant, planning a pregnancy, or are breastfeeding before taking this medicine. 

Major & minor side effects for ETHIXTHIO-MR Tablets

• Itching and skin rash
• Swelling of face, lips, eyelids, tongue, hands and feet 
• Nausea and Vomiting
• Yellowing of skin and eyes
• Dry mouth
• Headache
• Diarrhoea
• Dizziness
• Stomach pain
• Blurred vision
• Heart burn
• Loss of appetite
• Increase in blood pressure
• Drowsiness
   

Uses of ETHIXTHIO-MR Tablets
What is it prescribed for?
Relief from pain and swelling
ETHIXTHIO-MR Tablets is used to treat the pain and swelling associated with muscle spasms (a condition that causes involuntary contraction of muscles). It is used in conditions such as muscle pain, low back pain, neck pain, sprain/strains, etc. It is also used to relieve pain and swelling due to bone and joint conditions like ankylosing spondylitis (pain and stiffness of bones of the spine), osteoarthritis (tender and painful joints due to wear down of protective cartilage between the ends of the bones), rheumatoid arthritis (swelling and pain in the small joints of your body), etc. 

Commonly asked questions

How long does it take for this medicine to take effect?

The amount of time required for ETHIXTHIO-MR Tablets to show its action is not clinically established.

How long do the effects of this medicine last?

The amount of time for which ETHIXTHIO-MR Tablets remains active in your body is not clinically established.

Is it safe to consume alcohol while taking this medicine?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is this a habit forming medicine?

No habit forming tendency has been reported for ETHIXTHIO-MR Tablets.

Can this medicine be taken during pregnancy?

ETHIXTHIO-MR Tablets is not recommended for use during pregnancy as it may cause harm to your foetus. Consult your doctor if you are pregnant.

Can this medicine be taken while breast-feeding?

ETHIXTHIO-MR Tablets is not recommended for use in breastfeeding as it may pass into breastmilk. Consult your doctor if you are breastfeeding.

Allergy
Avoid taking ETHIXTHIO-MR Tablets if you are allergic to it. Serious allergic reactions to this medicine are rare. However, seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Peptic Ulcer
ETHIXTHIO-MR Tablets can cause stomach and intestinal bleeding. Therefore, this medicine is not recommended for use if you have peptic ulcers (sores in the lining of the stomach, small intestine, and food pipe) or bleeding in the stomach and intestine as it may worsen your health condition.
Severe Liver/Kidney Impairment
ETHIXTHIO-MR Tablets is not recommended for use if you have severe liver and/or kidney problems. This medicine may further damage your liver and/or kidneys and worsen your condition.
Heart diseases
ETHIXTHIO-MR Tablets is not recommended for use if you have heart problems such as heart failure (a condition in which your heart is unable to pump a sufficient amount of blood), ischaemic heart diseases (heart problems due to narrowing of the blood vessels that supply oxygen to the heart), high blood pressure that has not been adequately controlled or if you have undergone a coronary artery bypass graft surgery (a surgical procedure that diverts the blood from narrowed or blocked vessels in the heart to improve its blood supply). Taking this medicine may increase your risk of heart attack and stroke (a condition that occurs due to reduced blood supply to the brain).

Warnings for special population
Pregnancy
ETHIXTHIO-MR Tablets is not recommended for use during pregnancy as it may cause harm to your foetus. Consult your doctor if you are pregnant.
Breast-feeding
ETHIXTHIO-MR Tablets is not recommended for use in breastfeeding as it may pass into breastmilk. Consult your doctor if you are breastfeeding. 
General warnings
High blood pressure
ETHIXTHIO-MR Tablets can cause an increase in blood pressure. Hence, this medicine should be used with caution if you have high blood pressure as it may worsen your health condition. Keep a regular check of your blood pressure while taking this medicine.
Dehydration
ETHIXTHIO-MR Tablets should be used with caution if you are dehydrated as it may worsen your condition. Your doctor may correct such conditions first before starting the treatment. 
Infections
ETHIXTHIO-MR Tablets should be used with caution if you have any infection since it may mask the symptoms of an infection such as a fever. 
Diabetes
ETHIXTHIO-MR Tablets should be used with caution if you have diabetes (a condition of high sugar levels in your blood) or high cholesterol (fat) levels as it may increase the risk of heart problems. Consult your doctor before taking this medicine. 
Use in children
ETHIXTHIO-MR Tablets is not recommended for use in children below 16 years of age as the safety and efficacy data are not clinically established.
Oral contraceptive medicines
Avoid using birth control pills containing Ethinyl Estradiol along with ETHIXTHIO-MR Tablets as it may increase the risk of side effects. 
Other medicines
ETHIXTHIO-MR Tablets may interact with many other medicines and may cause severe side effects. Hence, inform your doctor about all your current medicines including any herbs and supplements before starting the treatment.
Driving or operating machines
ETHIXTHIO-MR Tablets may cause sleepiness, blurred vision, or dizziness in some cases. Hence, avoid driving vehicles and/or operating heavy machines if you experience such symptoms.
Impairment of fertility in men
ETHIXTHIO-MR Tablets may cause damage to sperm cells and lead to fertility problems in men. Therefore, discuss all the risks and benefits with your doctor before taking this medicine.
Use in women of childbearing potential
Women of childbearing potential should use effective contraceptive measures to avoid pregnancy during treatment with ETHIXTHIO-MR Tablets. A pregnancy test should be done to rule out pregnancy before beginning the treatment. If pregnancy is suspected during treatment, consult your doctor for further guidance.

Missed Dose
Try not to skip the scheduled dose of ETHIXTHIO-MR Tablets. If you miss a dose, take it as soon as you remember. If it is time for the next dose, skip the missed dose. Do not double the dose to make up for the missed one.
Overdose
Never take more than the prescribed dose of ETHIXTHIO-MR Tablets. Seek emergency medical attention in case of overdose for further guidance.

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Lithium
Ramipril
Warfarin
Ethinyl Estradiol
Rifampicin
Disease interactions
Fluid Retention and oedema
ETHIXTHIO-MR Tablets may cause fluid retention (abnormal build-up of fluid in the body) and lead to swelling of the legs and feet. ETHIXTHIO-MR Tablets should be used with caution in such conditions as it may further increase the risk of heart problems. Keep a regular check of your blood pressure and heart functions while taking this medicine. 
Heart Disease
ETHIXTHIO-MR Tablets should be used with caution if you have a history of heart problems as this medicine may cause heart attack and stroke. Report any incidence of heart problems to your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
Liver Disease
ETHIXTHIO-MR Tablets is broken down in your liver. Hence, this medicine should be used with caution if you have liver problems as it may lead to the accumulation of this medicine in your body and increase the risk of side effects. It may also cause further liver damage. Your doctor may suggest tests to closely monitor your liver function and liver enzyme levels while taking this medicine. 
Kidney Disease
ETHIXTHIO-MR Tablets should be used with caution if you have kidney problems as this medicine may further damage your kidneys. Your doctor may suggest tests to monitor your kidney function while taking this medicine.
Stomach ulcers or bleeding
ETHIXTHIO-MR Tablets should be used with caution as it may cause damage to the linings of your stomach and intestine. Conditions like bleeding, ulceration (sores in the lining of your stomach and intestine), and perforation (holes that form in the walls of the stomach and intestine) can occur. If you experience symptoms like indigestion, vomit with blood, or appearance of coffee-coloured dry blood in the stools, etc. consult your doctor immediately.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

Take ETHIXTHIO-MR Tablets with or without food as instructed by your doctor. 

Never take more than the prescribed dose. Take this medicine at the same time every day for ease of remembering.

Consult your doctor if your symptoms do not improve or become more severe. 

Miscelleneous
Can be taken with or without food, as advised by your doctor
To be taken as instructed by doctor
May cause sleepiness
How it works
ETHIXTHIO-MR Tablets is a combination of Etoricoxib and Thiocolchicoside.
Etoricoxib works by reducing the formation of certain substances in your body that cause pain and swelling. 
Thiocolchicoside is a muscle relaxant. It works in the brain and spinal cord to prevent muscle contractions and relieve muscle spasms.  
Legal Status
Approved
Unknown
Unknown
Unknown
Classification
Category
Nonsteroidal anti-inflammatory agents, Muscle relaxants, Analgesics
Schedule
Schedule H

• Etoricoxib: Drug monograph, National Library of Medicine (NIH)

• Thiocolchicoside: Drug monograph, National Center for Biotechnology Information (NCBI)

• European Medicines Agency (EMA) — Etoricoxib safety profile

• Indian Drug Regulatory Authority prescribing guidelines

• Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 13th Edition