CHYELITE™-D

5 ML

CHYELITE™-D is a pain-relieving medicine which is a combination of Trypsin, Rutoside, Bromelain and Diclofenac.

CHYELITE™-D provides effective relief from pain and swelling associated with ankylosing spondylitis (a type of arthritis where the bones of your spinal cord fuse together), osteoarthritis (painful swelling of your joints) and rheumatoid arthritis (a type of arthritis that affects the small joints of your body). It is also used to provide relief from headaches, toothaches, backaches, menstrual pain, ear pain, throat pain, sprains, and strains.

CHYELITE™-D shows some common side effects like nausea, vomiting, heartburn, stomach upset, loss of appetite, and diarrhoea. It may cause dizziness and blurred vision. Do not drive or do anything requiring your concentration after taking this medicine. It may change the colour and odour of your stool. This is not harmful but consult your doctor if it bothers you.

Avoid CHYELITE™-D if you are allergic to it. CHYELITE™-D should be taken with food at around the same time every day. If you missed a dose, take your next dose at the scheduled time.

Use CHYELITE™-D with extreme caution if you have liver and kidney problems. CHYELITE™-D is not recommended for children under 18 years of age, pregnant and breastfeeding women.

Major & minor side effects for Trypsin, Bromelain, Rutoside Triphydrate & Diclofenac Sodium Tablets

• Nausea or vomiting
• Heartburn
• Skin rash
• Dizziness
• Diarrhoea
• Indigestion
• Stomach upset
• Loss of appetite

What is it prescribed for?

• Pain and inflammation

Pain and inflammation (swelling) are common conditions that occur as a response of your immune system to protect your body from infection, injury, or disease. Trypsin, Bromelain, Rutoside Triphydrate & Diclofenac Sodium Tablets is used to relieve swelling and pain associated with conditions like back pain, muscle soreness, arthritis-related pain, ear pain, throat pain, sprain, strain, menstrual cramps, injury, toothaches and headaches.

Commonly asked questions

• How long does it take for this medicine to take effect?

CHYELITE™-D provides relief from pain and swelling within 1 to 2 hours.

• How long do the effects of this medicine last?

The effects of CHYELITE™-D lasts for 6 to 8 hours.

• Is it safe to consume alcohol while taking this medicine?

Consumption of alcohol is not recommended while treatment with CHYELITE™-D due to the risk of stomach bleeding.

• Is this a habit forming medicine?

No habit-forming tendencies were reported for CHYELITE™-D.

• Can this medicine be taken during pregnancy?

CHYELITE™-D is not recommended for use during pregnancy due to the risk of serious side effects for your developing foetus.

• Can this medicine be taken while breast-feeding?

CHYELITE™-D is not recommended for use in breastfeeding. Your doctor may prescribe an alternate medicine with the same therapeutic effect if necessary.

Allergy

Avoid taking CHYELITE™-D if you are allergic to it. Allergic reactions to this medicine are rare. Seek immediate medical attention if you notice any symptoms like a skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Gastrointestinal bleeding

CHYELITE™-D may cause stomach and intestinal bleeding and ulcers. Therefore it is not recommended for use in patients with perforation disorders (ex: appendicitis, ulcers, gall bladder disease, etc.) and acidity since it may worsen the condition.

Coronary Artery Bypass Surgery (CABG)

Do not use CHYELITE™-D for relieving pain after heart surgery.

Warnings for special population

Pregnancy

CHYELITE™-D is not recommended for use during pregnancy due to the risk of serious side effects for your developing foetus.

Breast-feeding

CHYELITE™-D is not recommended for use in breastfeeding. Your doctor may prescribe an alternate medicine with the same therapeutic effect if necessary.

General warnings

Skin allergies

CHYELITE™-D may cause serious skin allergies. These events may be severe in rare cases. If you develop signs and symptoms like rashes, hives (painful eruptions that sting and itch) or other allergic symptoms should be reported to your doctor immediately. Do not discontinue the treatment without talking to your doctor.

Change in the colour of stools

CHYELITE™-D may change the colour and odour of your stools. This is normal and does not harm you.

Driving or operating machinery

CHYELITE™-D may rarely cause dizziness, blurred vision, or drowsiness. Do not perform activities such as driving vehicles or operating machines if you experience any of these symptoms.

Use in children

CHYELITE™-D is not recommended for use in children below 18 years of age because safety and efficacy data is not available.

Missed Dose

If you miss to take a scheduled dose of CHYELITE™-D take it as soon as you remember. If it is almost time for your next dose skip the missed one. Do not double your dose to make up for the missed dose.

Overdose

Never take more than the prescribed dose of CHYELITE™-D. Seek emergency medical attention if you suspect that you might have taken an overdose of this medicine.

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while treatment with CHYELITE™-D due to the risk of stomach bleeding.

Interaction with Medicine

Ramipril

Digoxin

Warfarin

Disease interactions

Asthma

Patients with asthma may experience allergic reactions while taking CHYELITE™-D. It is not recommended for use if you have asthma, as it can trigger asthmatic episodes.

Kidney diseases

Long term use of high doses of CHYELITE™-D may cause kidney problems, such as painful urination and proteins or blood in the urine. You should use CHYELITE™-D with caution if you have kidney problems. Your doctor will suggest tests to closely monitor your kidney function.

Heart disease

Long-term use of CHYELITE™-D may increase the risk of a heart attack, especially if you have any pre-existing heart conditions. It is not recommended for treating pain after coronary bypass surgery.

Liver Disease

CHYELITE™-D should be used with caution if you have liver troubles, as it may increase the risk of liver failure.

Gastro-Intestinal toxicity

Long term use of CHYELITE™-D can cause damage to the stomach and intestine. Serious conditions like bleeding, ulceration, and perforation of the stomach or intestinal wall can occur. Any symptom like indigestion, the appearance of coffee coloured dry blood in stools or vomiting of blood should be reported immediately.

Food interactions

Information not available.

Lab interactions

Information not available.

This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

Take CHYELITE™-D with or without food. Never take more than the prescribed dose of this medicine. Do not give CHYELITE™-D to other people even if their condition appears to be the same as yours.

CHYELITE™-D may cause an increase in the symptom severity at the start of treatment. However, continue using it as prescribed by your doctor. Do not drive or do any activity requiring concentration until you know how CHYELITE™-D affects you.

Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works

Trypsin and Bromelain are enzymes that help in the breakdown of proteins involved in swelling and pain. Rutoside is an antioxidant that protects your body from damage by chemicals that cause swelling. Diclofenac stops the release of chemicals (prostaglandins) in your brain, that increase pain and swelling. Thus, CHYELITE™-D provide relief from your aches and swelling.

Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Nonsteroidal anti-inflammatory agents, Proteolytic enzyme, Analgesics, Anti-inflammatory agents

Schedule

Schedule H

Pubchem.ncbi.nlm.nih.gov. 2021. Bromelain. [online] Available at: < [Accessed 20 April 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Bromelain>

Pubchem.ncbi.nlm.nih.gov. 2021. Diclofenac. [online] Available at: < [Accessed 17 May 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Diclofenac>

Pubchem.ncbi.nlm.nih.gov. 2021. Trypsin. [online] Available at: < [Accessed 29 July 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/78383895>

Jcdr.net. 2021. JCDR - Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis - A Randomised Clinical Trial. [online] Available at: < [Accessed 11 August 2021].

https://www.jcdr.net/article_abstract.asp?id=9964>