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ETHRAB - INJECTION

Rabeprazole Sodium Injection I.P

PACKING SIZE / TYPE

10ML WITH CARTON

Summary

ETHRAB Injection is a proton pump inhibitor (PPI) designed for treating conditions related to excessive stomach acid production. It is primarily used to manage gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and ulcers in patients unable to take oral medication. This injection provides fast and effective relief by reducing stomach acid, protecting the gastrointestinal lining, and aiding in ulcer healing.

Side Effects

Common side effects include:

  • Nausea
  • Diarrhea or constipation
  • Headache
  • Injection site reactions (redness, swelling, or pain)
  • Flatulence

Rare but serious side effects:

  • Severe allergic reactions (rash, swelling, or difficulty breathing)
  • Low magnesium levels (muscle cramps, seizures, or irregular heartbeat)
  • Bone fractures with long-term use

Usage

  • Administered via intravenous (IV) route under medical supervision.
  • Typically used when oral administration is not feasible.

Concerns

  • Elderly Patients: Increased risk of fractures and low magnesium levels.
  • Long-term Use: Associated with vitamin B12 deficiency and stomach infections.

When not to use?

  • Hypersensitivity to Rabeprazole Sodium or other PPIs.
  • Severe hepatic impairment (use with caution).
  • Not recommended in patients with a known allergy to any excipients in the formulation.

Warnings

  • Pregnancy and Lactation: Use only if clearly needed and prescribed by a healthcare professional.
  • Pediatric Use: Safety and efficacy not established for children.
  • Bone Health: Prolonged use may lead to osteoporosis-related fractures.
  • Infections: Increased risk of Clostridium difficile-associated diarrhea.

Dosage

  • Typical adult dose: 20 mg once daily, adjusted as per the condition being treated.
  • Dosage and duration depend on clinical response and severity of the condition.

Interactions

  • Antacids: May alter the absorption of Rabeprazole.
  • Warfarin: Increased risk of bleeding; monitor INR.
  • Digoxin: May enhance serum levels of digoxin.
  • Clopidogrel: Reduced effectiveness of clopidogrel when used concomitantly.

General Instructions

  • Administer only under the guidance of a qualified healthcare provider.
  • Avoid abrupt discontinuation; follow the prescribed course.
  • Report any unusual symptoms or side effects to the healthcare professional promptly.

Other Details

  • Storage: Keep vials in a cool, dry place away from sunlight.
  • Packaging: Available as a sterile single-use vial.

References

  • Product information leaflet for Rabeprazole Sodium Injection I.P.

  • Clinical guidelines for the use of proton pump inhibitors.

  • FDA drug database for Rabeprazole Sodium.

  • Recent studies on the safety and efficacy of Rabeprazole in intravenous formulations.

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