ETHKACIN - 500MG

500MG / 2ML For I.M./ I.V .Use Only

ETHKACIN-500MG contains Amikacin Sulphate, an aminoglycoside antibiotic used to treat severe bacterial infections caused by gram-negative organisms. It works by inhibiting bacterial protein synthesis, thus preventing bacterial growth and proliferation. It is typically used in hospital settings for infections of the respiratory tract, urinary tract, bones, joints, and skin.

• Common: Nausea, vomiting, injection site reactions (pain, redness).
• Serious: Hearing loss (ototoxicity), kidney damage (nephrotoxicity), balance issues, allergic reactions (rash, itching, swelling).
• Rare: Respiratory paralysis in susceptible individuals.

• Administered via intravenous (IV) or intramuscular (IM) injection under medical supervision.
• Dosage varies based on body weight, type of infection, and renal function.
• Ensure hydration to minimize nephrotoxicity risks.

Monitoring: Regular monitoring of kidney function, hearing ability, and blood drug levels is required.

Resistance: Overuse or misuse can lead to antibiotic resistance

• Known allergy to Amikacin or other aminoglycosides.
• Patients with severe renal impairment or pre-existing hearing loss.
• Myasthenia gravis: May worsen muscle weakness.
• Pregnancy: Use only if absolutely necessary, as it may harm the fetus.

• Ototoxicity: Avoid in patients with auditory nerve damage.
• Nephrotoxicity: Higher risk in elderly or dehydrated individuals; ensure proper hydration.
• Neuromuscular blockade: Risk of respiratory paralysis in high doses or in combination with anesthetics or neuromuscular blockers.
• Avoid prolonged use: To minimize toxicity risks.

• Adults: Typically, 15 mg/kg/day in divided doses every 8 or 12 hours. Adjustments needed for renal impairment.
• Children and Neonates: Dosage based on weight and condition, under strict medical supervision.
• Renal Impairment: Doses should be adjusted based on creatinine clearance.

• Medications: Enhanced nephrotoxicity with other nephrotoxic drugs (e.g., vancomycin, amphotericin B).
• Anesthetics or neuromuscular blockers: Increased risk of respiratory depression.
• Loop diuretics: Higher ototoxicity risk.

• Use only under the supervision of a healthcare professional.
• Maintain adequate hydration to reduce toxicity risks.
• Report any signs of hearing loss, balance issues, or reduced urine output.
• Complete the full course even if symptoms improve early.

• Storage: Store below 25°C. Protect from light and freezing.
• Packaging: Available in sterile vials for injection.

• Clinical guidelines on aminoglycosides therapy.

• Manufacturer’s product insert.

• Relevant medical literature on amikacin pharmacology and usage.